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To reach the Sistine Chapel from Rome Termini, you can take the metro Line A towards Battistini and get off at the Ottaviano-San Pietro stop. Then it's about a 15-20 minute walk to the Sistine Chapel. Alternatively, you can take bus number 64 towards San Pietro and get off at the last stop. From there, it's about a 5-minute walk to the Sistine Chapel.
No, the Sistine Chapel is not open every day. It is closed on Sundays and on certain religious holidays. It can also be closed for special events, such as the election of a new pope or restoration work. It's recommended to check the official website or contact them for the latest information and to book your tickets in advance as it can get busy, especially during peak tourist season.